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Parents’ knowledge,attitudes, use of pain relief methods and satisfaction related to their children's postoperative pain management: a descriptive correlational study 下载免费PDF全文
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‘Let's talk about sex’ – A Knowledge,Attitudes and Practice study among Paediatric Nurses about Teen Sexual Health in Hong Kong 下载免费PDF全文
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Association of TNFAIP3 and TNFRSF1A variation with multiple sclerosis in a German case–control cohort 下载免费PDF全文
S. Hoffjan A. Okur J. T. Epplen S. Wieczorek A. Chan D. A. Akkad 《International journal of immunogenetics》2015,42(2):106-110
Variations in two genes of the tumour necrosis factor (TNF) alpha pathway have been implicated in the pathogenesis of autoimmune diseases: polymorphisms in the TNFRSF1A gene, encoding TNF receptor 1, showed significant association with MS in genomewide association scans, and variation in or near the TNFAIP3 gene, coding for a negative regulator of NFkB, was associated with MS, systemic lupus erythematosus, diabetes and rheumatoid arthritis. This study aimed at investigating association of MS with variation in the TNFRSF1A gene as well as in the TNFAIP3 gene region in an independent German case–control cohort. Four hundred and ninety‐seven unrelated patients with MS and 878 healthy controls were genotyped with restriction enzyme digestion or TaqMan assays for three polymorphisms in the TNFRSF1A gene and seven in the region of the TNFAIP3 gene. Allele, genotype and haplotype frequencies were compared between cases and controls by chi‐square testing. We found significant association of rs10499194, located in the intergenic region upstream of TNFAIP3, with MS (pc = 3.4 × 10?4). Further, the intronic SNP rs1800693 in TNFRSF1A showed moderate association (pc = 0.033) with MS. In conclusion, evidence is accumulating that polymorphisms in both TNFAIP3 and TNFRSF1A genes play a role in MS pathogenesis. Additional studies are warranted to further elucidate the role of TNF pathway variation for MS development. 相似文献
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Paul Tieu Bosco Paes Afrah Ahmed Davide Matino Anthony Chan Mihir Bhatt 《Pediatric blood & cancer》2020,67(4)
Neonatal inferior vena cava syndrome (IVCS), though uncommon, is associated with significant morbidity and mortality. Information on risk factors, diagnosis, treatment, and outcomes is limited. This review comprised 61 neonates across 33 reports. Thrombosis occurred in 98% and 42% involved a central venous catheter. Diagnosis was mainly established by ultrasound in 82%. Therapeutically, heparin was employed in 36% and thrombolysis in 18% of the cases. The overall mortality was 23%. An algorithm of clinical signs, investigation, and management is presented. Well‐designed prospective studies are needed to establish a concrete investigational approach to neonatal IVCS and institute safe, evidence‐based treatment. 相似文献
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The reliability and validity of the pain items of the Hong Kong version interRAI community health assessment for community‐dwelling elders in Hong Kong 下载免费PDF全文
Justina YW Liu PhD RN Iris Chi DSW Kin‐Sun Chan PhD Claudia KY Lai PhD RN Angela YM Leung PhD RN 《Journal of clinical nursing》2015,24(15-16):2352-2354